BPC-157
Body Protection Compound pentadecapeptide
BPC-157 is a 15-amino-acid fragment of a protective protein found in gastric juice. It is among the most extensively studied peptides in preclinical healing research. Supplied lyophilized, one 10mg vial.
About BPC-157
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide — fifteen amino acids — whose sequence is taken from a protective protein isolated from human gastric juice. It was first described by Predrag Sikirić and colleagues at the University of Zagreb, whose group has published the majority of the several hundred animal studies on it since the early 1990s.
In those studies BPC-157 has been examined for effects on the healing of tendon, ligament, muscle, bone, skin and the gastrointestinal lining, on blood-vessel formation and on the gut–brain axis. Unusually for a peptide, it is reported to be stable in gastric acid. Human data remain very limited: a Phase 1 safety study and a small retrospective case series. It is not approved by any regulator and is prohibited in sport by WADA.
Mechanism
Proposed mechanisms from animal work include up-regulation of growth-hormone receptor expression in fibroblasts, activation of the FAK–paxillin pathway that drives cell migration, modulation of the nitric-oxide system and promotion of new blood-vessel growth via VEGFR2. Its gastric stability and effects on gut healing are why it is often described as a 'cytoprotective' peptide in the literature.
Areas of research
- Studied for accelerated tendon-to-bone healing in rodent models
- Investigated for gastrointestinal mucosal protection
- Research interest in angiogenesis and nitric-oxide pathway modulation
- Stable in gastric acid — unusual for a peptide of its size
References
- Sikiric P et al. Brain-gut axis and pentadecapeptide BPC 157: theoretical and practical implications. Curr Neuropharmacol. 2016;14(8):857-865. PubMed
- Chang CH et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol. 2011;110(3):774-780. PubMed
- Seiwerth S et al. BPC 157 and standard angiogenic growth factors. Gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing. Curr Pharm Des. 2018;24(18):1972-1989. PubMed
Research use only. Information on this page is provided for educational and research purposes and summarises published literature, mostly from cell and animal studies; it is not a claim of efficacy or safety. Products are not intended for human or veterinary use, or for any diagnostic or therapeutic purpose.
Molecular details
- Class
- Pentadecapeptide, gastric-juice derived
- Sequence
- Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (GEPPPGKPADDAGLV)
- Length
- 15 amino acids
- Molecular formula
- C62H98N16O22
- Molecular weight
- 1419.6 g/mol
- CAS number
- 137525-51-0
- Form
- Lyophilized powder, 10 mg per vial
Storage
Lyophilized: store cool, dark and dry — refrigeration is ideal. Once reconstituted, refrigerate at 2–8 °C.
Reconstitution
Reconstitute with bacteriostatic water.
Handling
Readily soluble in bacteriostatic water (1 mL per 10 mg vial gives 10 mg/mL; 2 mL gives 5 mg/mL). Swirl gently until the solution is clear. BPC-157 is one of the more stable short peptides, but the same rules apply: keep lyophilized vials cold and dark, refrigerate solution at 2–8 °C, and avoid repeated freezing.
Details
BPC-157 · 10mg
Recovery & Tissue Repair
Lyophilized powder, sealed vial
