BPC-157 / TB-500
Dual tissue-repair blend (10mg + 10mg)
A combined vial of BPC-157 and TB-500, the two most-cited peptides in tissue-repair research. BPC-157 is a gastric-derived pentadecapeptide; TB-500 is derived from thymosin beta-4. Supplied lyophilized, 10mg of each in a single 20mg vial.
About BPC-157 / TB-500
This vial combines two of the most-studied peptides in tissue-repair research, 10 mg of BPC-157 and 10 mg of TB-500, lyophilized together so that a single reconstitution yields both compounds in one solution.
BPC-157 is a 15-amino-acid fragment of Body Protection Compound, a protein found in human gastric juice, studied since the 1990s for effects on tendon, ligament, muscle and gut healing in animal models. TB-500 is a synthetic form of thymosin β4, the 43-amino-acid actin-binding protein that is one of the most abundant peptides in mammalian cells and is released at sites of injury. Products sold as TB-500 contain either the full-length peptide or its N-acetylated 17–23 fragment (Ac-LKKTETQ), the segment that binds actin.
The two are combined in research because they act on different parts of the repair process — BPC-157 on growth-factor signalling and blood-vessel formation, thymosin β4 on cell migration and the actin cytoskeleton. Neither is approved for human use; both are prohibited by the World Anti-Doping Agency.
Mechanism
In animal studies BPC-157 up-regulates growth-factor receptors, promotes angiogenesis through VEGF and nitric-oxide pathways and accelerates fibroblast migration. Thymosin β4 sequesters G-actin, which regulates actin polymerisation and lets cells migrate into a wound; it also down-regulates inflammatory cytokines and promotes endothelial cell migration. See the individual BPC-157 page for more on that peptide.
Areas of research
- BPC-157: studied for tendon, ligament and gastrointestinal repair in animal models
- TB-500: actin-binding peptide studied for cell migration and wound closure
- Combination widely used in preclinical musculoskeletal recovery research
- Both compounds are water-soluble and stable when lyophilized
References
- Chang CH et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol. 2011;110(3):774-780. PubMed
- Goldstein AL, Hannappel E, Kleinman HK. Thymosin β4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med. 2005;11(9):421-429. PubMed
- Ho ENM et al. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential. Drug Test Anal. 2012;4(6):434-438. PubMed
Research use only. Information on this page is provided for educational and research purposes and summarises published literature, mostly from cell and animal studies; it is not a claim of efficacy or safety. Products are not intended for human or veterinary use, or for any diagnostic or therapeutic purpose.
Molecular details
- Contents
- BPC-157 10 mg + TB-500 10 mg
- BPC-157
- GEPPPGKPADDAGLV · C62H98N16O22 · 1419.6 g/mol · CAS 137525-51-0
- Thymosin β4 (full length)
- 43 amino acids · ≈ 4963 g/mol · CAS 77591-33-4
- Tβ4 fragment 17–23
- Ac-LKKTETQ · ≈ 890 g/mol
- Form
- Lyophilized powder, 20 mg total per vial
Storage
Lyophilized: store cool, dark and dry — refrigeration is ideal. Once reconstituted, refrigerate at 2–8 °C.
Reconstitution
Reconstitute with bacteriostatic water.
Handling
Reconstitute with bacteriostatic water: 2 mL per vial gives 5 mg/mL of each peptide. Run the solvent down the side of the vial and swirl gently until clear. Both peptides are stable lyophilized when kept cold and dark; once in solution keep at 2–8 °C. BPC-157 is comparatively robust in solution; thymosin β4 is best used within a few weeks of reconstitution.
Details
BPC-157 / TB-500 · 20mg
Recovery & Tissue Repair
Lyophilized powder, sealed vial
