Klow
GHK-Cu · BPC-157 · TB-500 · KPV blend
Klow is a four-peptide blend combining GHK-Cu, BPC-157, TB-500 and KPV in a single vial. It brings together the copper peptide most studied for collagen remodelling with three repair and anti-inflammatory peptides. Supplied lyophilized, 80mg total per vial.
About Klow
Klow is a four-compound blend: GHK-Cu, BPC-157, TB-500 and KPV, lyophilized together in an 80 mg vial. Each component is profiled on its own page; the blend exists so that all four can be reconstituted from a single vial for research on tissue repair and inflammation, where they are frequently studied together.
The four act on distinct pathways — GHK-Cu on collagen and gene expression, BPC-157 on growth-factor and angiogenic signalling, thymosin β4 (TB-500) on cell migration, and KPV on melanocortin-mediated anti-inflammatory signalling — which is the rationale for combining them. The copper complex gives the reconstituted solution a blue tint; that is expected, not a sign of contamination.
Mechanism
GHK-Cu delivers copper to enzymes such as lysyl oxidase and modulates the expression of thousands of genes involved in tissue remodelling. BPC-157 promotes angiogenesis and fibroblast migration. Thymosin β4 regulates actin polymerisation and cell movement into injured tissue. KPV, the C-terminal tripeptide of α-MSH, reduces NF-κB-driven inflammatory signalling. Together they cover the inflammatory, proliferative and remodelling phases of repair that are studied in wound-healing models.
Areas of research
- GHK-Cu: copper-binding tripeptide studied for collagen synthesis and tissue remodelling
- BPC-157 and TB-500: the standard pairing in musculoskeletal repair research
- KPV: alpha-MSH fragment studied for anti-inflammatory signalling
- Single-vial format simplifies handling for combined protocols
References
- Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. Int J Mol Sci. 2018;19(7):1987. PubMed
- Brzoska T et al. α-Melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo. Endocr Rev. 2008;29(5):581-602. PubMed
Research use only. Information on this page is provided for educational and research purposes and summarises published literature, mostly from cell and animal studies; it is not a claim of efficacy or safety. Products are not intended for human or veterinary use, or for any diagnostic or therapeutic purpose.
Molecular details
- Contents
- GHK-Cu + BPC-157 + TB-500 + KPV, 80 mg total
- GHK-Cu
- Gly-His-Lys · copper(II) complex · CAS 89030-95-5
- BPC-157
- GEPPPGKPADDAGLV · 1419.6 g/mol · CAS 137525-51-0
- TB-500
- Thymosin β4 / Ac-LKKTETQ fragment
- KPV
- Lys-Pro-Val · 342.4 g/mol · CAS 67727-97-3
- Form
- Lyophilized powder, 80 mg per vial
Storage
Lyophilized: store cool, dark and dry — refrigeration is ideal. Once reconstituted, refrigerate at 2–8 °C.
Reconstitution
Reconstitute with bacteriostatic water. Solution will be blue from the copper complex — this is expected.
Handling
Reconstitute with bacteriostatic water — 2 to 4 mL per vial depending on the working concentration you need. Swirl gently; the copper complex dissolves to a clear blue solution. Keep the vial cold and dark before and after reconstitution (2–8 °C) and protect from light; GHK-Cu is light- and pH-sensitive.
Details
Klow · 80mg
Recovery & Tissue Repair
Lyophilized powder, sealed vial
